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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

1. A patient develops a severe diarrheal illness after consuming raw seafood. Stool culture yields a Gram- negative, comma-shaped bacterium that is oxidase-positive and grows on thiosulfate-citrate-bile salts-sucrose (TCBS) agar, producing blue-green colonies. The MOST significant virulence factor contributing to the severe, cholera-like diarrhea caused by this organism is:

A) Heat-labile toxin (LT)
B) Heat-stable enterotoxin (ST)
C) Type III secretion system (T3SS)
D) Cholera toxin (CT)-like enterotoxin

2. During the processing of stool specimens for ova and parasite examination, the formalin-ethyl acetate concentration procedure primarily serves to:

A) Stain parasite nuclei for easier identification
B) Preserve parasite morphology and kill bacteria
C) Selectively culture protozoan trophozoites
D) Separate parasites from fecal debris and concentrate them

3. A research laboratory is investigating the mechanism of action of a novel antiviral compound. In vitro studies demonstrate that the compound effectively inhibits the replication of a specific enveloped RNA virus. Further analysis reveals that the compound does not interfere with viral entry, genome replication, or protein synthesis. However, electron microscopy of infected cells treated with the compound shows an accumulation of viral glycoproteins within the endoplasmic reticulum and Golgi apparatus, with a significant reduction in the release of infectious virions. The MOST likely target of this antiviral compound is:

A) Viral protease responsible for polyprotein cleavage
B) Host cell membrane fusion machinery
C) Viral RNA-dependent RNA polymerase
D) Viral glycoprotein trafficking and maturation

4. A patient with HIV infection and a low CD4+ T-cell count presents with fever, weight loss, and cough. Chest X-ray shows diffuse interstitial infiltrates. Sputum induction reveals oval yeast cells with narrow-based budding. The MOST likely diagnosis is:

A) Cryptococcosis
B) Pneumocystis pneumonia
C) Tuberculosis
D) Histoplasmosis

5. During a primary infection with Epstein-Barr virus (EBV), the virus establishes latency in B lymphocytes.
The transition from lytic to latent infection is tightly regulated by viral gene expression. Which of the following viral proteins is crucial for the establishment and maintenance of EBV latency and is a key target in EBV-associated lymphomas?

A) Glycoprotein gp350
B) Viral capsid antigen (VCA)
C) Early antigen (EA)
D) Epstein-Barr nuclear antigen 1 (EBNA1)

Solutions: